| Item Type | Name |
|
Concept
|
Altitude Sickness
|
|
Concept
|
5-Aminolevulinate Synthetase
|
|
Concept
|
Adsorption
|
|
Concept
|
Bioelectric Energy Sources
|
|
Concept
|
Alleles
|
|
Concept
|
Amino Acid Sequence
|
|
Concept
|
Adenosine Triphosphate
|
|
Concept
|
Blood Proteins
|
|
Concept
|
Carbohydrate Sequence
|
|
Concept
|
Cell Fractionation
|
|
Concept
|
Chromatography, DEAE-Cellulose
|
|
Concept
|
Computer Simulation
|
|
Concept
|
Base Sequence
|
|
Concept
|
Biological Assay
|
|
Concept
|
Carboxy-Lyases
|
|
Concept
|
Binding Sites
|
|
Concept
|
Cell Separation
|
|
Concept
|
Brain Mapping
|
|
Concept
|
Brain Stem
|
|
Concept
|
Chromatography, Gel
|
|
Concept
|
Centrifugation, Density Gradient
|
|
Concept
|
Chromosome Mapping
|
|
Concept
|
Chromatography, Thin Layer
|
|
Concept
|
Computer Systems
|
|
Concept
|
Chromatography, Ion Exchange
|
|
Concept
|
Dimethyl Sulfoxide
|
|
Concept
|
DNA-Binding Proteins
|
|
Concept
|
Drug Synergism
|
|
Concept
|
Education
|
|
Concept
|
Endarterectomy
|
|
Concept
|
Database Management Systems
|
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
|
Concept
|
Glycogen Synthase
|
|
Concept
|
Epidemiologic Methods
|
|
Concept
|
Chromatography
|
|
Concept
|
Chromatography, High Pressure Liquid
|
|
Concept
|
Eye Proteins
|
|
Concept
|
Cross-Sectional Studies
|
|
Concept
|
Disease Susceptibility
|
|
Concept
|
Double-Blind Method
|
|
Concept
|
Food Supply
|
|
Concept
|
Electrophoresis
|
|
Concept
|
Decerebrate State
|
|
Concept
|
Genes, Dominant
|
|
Concept
|
Fasting
|
|
Concept
|
Neurosecretory Systems
|
|
Concept
|
Nutritional Status
|
|
Concept
|
Oceans and Seas
|
|
Concept
|
Histocytochemistry
|
|
Concept
|
Electron Spin Resonance Spectroscopy
|
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Erythrocyte Indices
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Fluorescent Antibody Technique
|
|
Concept
|
Fluorometry
|
|
Concept
|
Image Interpretation, Computer-Assisted
|
|
Concept
|
Fourier Analysis
|
|
Concept
|
Membrane Proteins
|
|
Concept
|
Mice, Inbred Strains
|
|
Concept
|
Nerve Tissue Proteins
|
|
Concept
|
Immunization, Secondary
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Organ Culture Techniques
|
|
Concept
|
Organ Size
|
|
Concept
|
Molecular Sequence Data
|
|
Concept
|
Monosaccharide Transport Proteins
|
|
Concept
|
Muscle, Smooth, Vascular
|
|
Concept
|
Radioligand Assay
|
|
Concept
|
Rats, Inbred SHR
|
|
Concept
|
Receptors, Somatotropin
|
|
Concept
|
Repetitive Sequences, Nucleic Acid
|
|
Concept
|
Melanocyte-Stimulating Hormones
|
|
Concept
|
Selection, Genetic
|
|
Concept
|
Oximetry
|
|
Concept
|
Perfusion
|
|
Concept
|
Spermine
|
|
Concept
|
Spin Labels
|
|
Concept
|
Stimulation, Chemical
|
|
Concept
|
Stress, Physiological
|
|
Concept
|
Muscle Proteins
|
|
Concept
|
Magnetic Resonance Spectroscopy
|
|
Concept
|
Sulfones
|
|
Concept
|
Procollagen
|
|
Concept
|
Prediabetic State
|
|
Concept
|
Proinsulin
|
|
Concept
|
Protein Precursors
|
|
Concept
|
Protein-Tyrosine Kinases
|
|
Concept
|
Protein Binding
|
|
Concept
|
Protein Conformation
|
|
Concept
|
Protein Processing, Post-Translational
|
|
Concept
|
Proteoglycans
|
|
Concept
|
Proto-Oncogene Proteins
|
|
Concept
|
Pseudogenes
|
|
Concept
|
Protease Inhibitors
|
|
Concept
|
Proteins
|
|
Concept
|
Glucose Tolerance Test
|
|
Concept
|
Image Processing, Computer-Assisted
|
|
Concept
|
Immunoassay
|
|
Concept
|
Immunoenzyme Techniques
|
|
Concept
|
Radiometry
|
|
Concept
|
Receptors, Cell Surface
|
|
Concept
|
Repressor Proteins
|
|
Concept
|
Protein Kinases
|
|
Concept
|
Schools
|
|
Concept
|
Sequence Homology, Nucleic Acid
|
|
Concept
|
Intestine, Small
|
|
Concept
|
Soil Pollutants
|
|
Concept
|
Solutions
|
|
Concept
|
Somatostatin
|
|
Concept
|
Species Specificity
|
|
Concept
|
Cohort Studies
|
|
Concept
|
Genes, ras
|
|
Concept
|
Regulatory Sequences, Nucleic Acid
|
|
Concept
|
Sexual Behavior, Animal
|
|
Concept
|
RNA Splicing
|
|
Concept
|
Smoking
|
|
Concept
|
Sodium
|
|
Concept
|
Spectrum Analysis
|
|
Concept
|
Serotonin
|
|
Concept
|
Spermatogonia
|
|
Concept
|
Squalene
|
|
Concept
|
Sensitivity and Specificity
|
|
Concept
|
Sex Attractants
|
|
Concept
|
Soil Microbiology
|
|
Concept
|
Solar Energy
|
|
Concept
|
Spermidine
|
|
Concept
|
Starvation
|
|
Concept
|
Sulfonylurea Compounds
|
|
Concept
|
Swine
|
|
Concept
|
Synovitis
|
|
Concept
|
Technology Assessment, Biomedical
|
|
Concept
|
Skin
|
|
Concept
|
Sympathetic Nervous System
|
|
Concept
|
Tomography, Emission-Computed
|
|
Concept
|
Protein Biosynthesis
|
|
Concept
|
Succinates
|
|
Concept
|
Sulfonium Compounds
|
|
Concept
|
Synapses
|
|
Concept
|
Space-Time Clustering
|
|
Concept
|
Spectrum Analysis, Raman
|
|
Concept
|
Stem Cells
|
|
Concept
|
Genome
|
|
Concept
|
Ultrasonography
|
|
Concept
|
United States
|
|
Concept
|
Sequence Homology, Amino Acid
|
|
Concept
|
Randomized Controlled Trials as Topic
|
|
Concept
|
Risk Assessment
|
|
Concept
|
Cell Culture Techniques
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
rac1 GTP-Binding Protein
|
|
Concept
|
Mitogen-Activated Protein Kinases
|
|
Concept
|
Protein Subunits
|
|
Concept
|
Extracellular Matrix Proteins
|
|
Concept
|
Prosencephalon
|
|
Concept
|
Electrophoretic Mobility Shift Assay
|
|
Concept
|
HMGA1a Protein
|
|
Concept
|
Deoxyribonucleases, Type II Site-Specific
|
|
Concept
|
Glucose Clamp Technique
|
|
Concept
|
Genes, Tumor Suppressor
|
|
Concept
|
Genes, jun
|
|
Concept
|
Microinjections
|
|
Concept
|
Milk Proteins
|
|
Concept
|
Cysteine Proteinase Inhibitors
|
|
Concept
|
Proto-Oncogene Proteins c-fos
|
|
Concept
|
Rats, Sprague-Dawley
|
|
Concept
|
Cyclic AMP Response Element-Binding Protein
|
|
Concept
|
Mutagenesis, Site-Directed
|
|
Concept
|
Sequence Alignment
|
|
Concept
|
Drug Delivery Systems
|
|
Concept
|
Case-Control Studies
|
|
Concept
|
Alternative Splicing
|
|
Concept
|
Sequence Analysis, DNA
|
|
Concept
|
Protein Structure, Tertiary
|
|
Concept
|
Genes, Reporter
|
|
Concept
|
Microscopy, Electron, Scanning
|
|
Concept
|
Paraffin Embedding
|
|
Concept
|
Amyloid beta-Protein Precursor
|
|
Concept
|
RNA-Binding Proteins
|
|
Concept
|
Immediate-Early Proteins
|
|
Concept
|
Solitary Nucleus
|
|
Concept
|
Patch-Clamp Techniques
|
|
Concept
|
Cell Proliferation
|
|
Concept
|
Insulin-Like Growth Factor Binding Protein 1
|
|
Concept
|
Oxidative Stress
|
|
Concept
|
Disease Progression
|
|
Concept
|
Muscle, Skeletal
|
|
Concept
|
ras Proteins
|
|
Concept
|
Qa-SNARE Proteins
|
|
Concept
|
Spodoptera
|
|
Concept
|
Simvastatin
|
|
Concept
|
Staurosporine
|
|
Concept
|
Bone Morphogenetic Protein Receptors, Type II
|
|
Concept
|
Nitric Oxide Synthase Type I
|
|
Concept
|
Receptor Protein-Tyrosine Kinases
|
|
Concept
|
Protein Transport
|
|
Concept
|
Calcium Signaling
|
|
Concept
|
Cross-Over Studies
|
|
Concept
|
src Homology Domains
|
|
Concept
|
Geologic Sediments
|
|
Concept
|
SOXF Transcription Factors
|
|
Concept
|
Gene Knockout Techniques
|
|
Concept
|
Reactive Oxygen Species
|
|
Concept
|
Protein Folding
|
|
Concept
|
Genetic Association Studies
|
|
Concept
|
HMGB Proteins
|
|
Concept
|
Mitochondrial Proteins
|
|
Concept
|
Endoplasmic Reticulum Stress
|
|
Concept
|
Intercellular Signaling Peptides and Proteins
|
|
Concept
|
Primary Cell Culture
|
|
Concept
|
Receptors, G-Protein-Coupled
|
|
Concept
|
Proprotein Convertase 2
|
|
Concept
|
Positron-Emission Tomography
|
|
Concept
|
Green Fluorescent Proteins
|
|
Concept
|
Proteomics
|
|
Concept
|
Mutant Chimeric Proteins
|
|
Concept
|
Scavenger Receptors, Class E
|
|
Concept
|
Microarray Analysis
|
|
Concept
|
Protein Kinase C-delta
|
|
Concept
|
Hypoxia-Inducible Factor 1, alpha Subunit
|
|
Concept
|
Proteasome Endopeptidase Complex
|
|
Concept
|
Mitogen-Activated Protein Kinase 3
|
|
Concept
|
Biological Specimen Banks
|
|
Concept
|
Microscopy, Confocal
|
|
Concept
|
Ribosomal Protein S6 Kinases
|
|
Concept
|
Proto-Oncogene Proteins c-raf
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
SNARE Proteins
|
|
Concept
|
Cell Cycle Proteins
|
|
Concept
|
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
|
|
Concept
|
rab3 GTP-Binding Proteins
|
|
Concept
|
Bone Morphogenetic Proteins
|
|
Concept
|
Sirolimus
|
|
Concept
|
Proteome
|
|
Concept
|
I-kappa B Proteins
|
|
Concept
|
rab3A GTP-Binding Protein
|
|
Concept
|
Gene Expression Profiling
|
|
Concept
|
STAT3 Transcription Factor
|
|
Concept
|
Oncogene Protein v-akt
|
|
Concept
|
Reactive Nitrogen Species
|
|
Concept
|
Saccharomyces cerevisiae Proteins
|
|
Concept
|
Electric Power Supplies
|
|
Concept
|
Prognosis
|
|
Concept
|
Precipitin Tests
|
|
Concept
|
Pro-Opiomelanocortin
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Protein Kinase C-epsilon
|
|
Concept
|
Protein Kinase C
|
|
Concept
|
Recombinant Proteins
|
|
Concept
|
Renin-Angiotensin System
|
|
Concept
|
Radioimmunoassay
|
|
Concept
|
Rats, Inbred Strains
|
|
Concept
|
RNA, Double-Stranded
|
|
Concept
|
Saliva
|
|
Concept
|
Serine
|
|
Concept
|
Severity of Illness Index
|
|
Concept
|
Tandem Mass Spectrometry
|
|
Concept
|
Myocytes, Smooth Muscle
|
|
Concept
|
Satiety Response
|
|
Concept
|
Scattering, Radiation
|
|
Concept
|
Secretory Rate
|
|
Concept
|
Glycogen Synthase Kinases
|
|
Concept
|
Glycogen Synthase Kinase 3
|
|
Concept
|
Soil
|
|
Concept
|
Stochastic Processes
|
|
Concept
|
Proprotein Convertases
|
|
Concept
|
Sulfonamides
|
|
Concept
|
Biomedical Research
|
|
Concept
|
Bone Morphogenetic Protein 4
|
|
Concept
|
Proprotein Convertase 1
|
|
Concept
|
Shc Signaling Adaptor Proteins
|
|
Concept
|
Prolactin-Releasing Hormone
|
|
Concept
|
Calcitonin Receptor-Like Protein
|
|
Concept
|
Synaptotagmins
|
|
Concept
|
Sterol Regulatory Element Binding Protein 1
|
|
Concept
|
Nitric Oxide Synthase Type II
|
|
Concept
|
TOR Serine-Threonine Kinases
|
|
Concept
|
High-Throughput Nucleotide Sequencing
|
|
Concept
|
Genotyping Techniques
|
|
Concept
|
Culture Techniques
|
|
Concept
|
Immunoprecipitation
|
|
Concept
|
Sex Factors
|
|
Concept
|
Sialic Acids
|
|
Concept
|
Influenza A Virus, H1N1 Subtype
|
|
Concept
|
Spermatocytes
|
|
Concept
|
Streptozocin
|
|
Concept
|
Subcellular Fractions
|
|
Concept
|
Substrate Specificity
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Insulin-Secreting Cells
|
|
Concept
|
Immunoblotting
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Models, Statistical
|
|
Concept
|
R-SNARE Proteins
|
|
Concept
|
Synaptotagmin I
|
|
Concept
|
HSP40 Heat-Shock Proteins
|
|
Concept
|
Vesicle-Associated Membrane Protein 3
|
|
Concept
|
Inhibitor of Differentiation Protein 1
|
|
Concept
|
Logistic Models
|
|
Concept
|
Survival Analysis
|
|
Concept
|
Neuroanatomical Tract-Tracing Techniques
|
|
Concept
|
Islets of Langerhans Transplantation
|
|
Concept
|
Mice, 129 Strain
|
|
Concept
|
Transfection
|
|
Concept
|
Bone Morphogenetic Protein Receptors, Type I
|
|
Concept
|
Viral Proteins
|
|
Concept
|
Blotting, Southern
|
|
Concept
|
Blotting, Northern
|
|
Concept
|
Genetic Therapy
|
|
Concept
|
Molecular Probe Techniques
|
|
Concept
|
Molecular Structure
|
|
Concept
|
Single-Strand Specific DNA and RNA Endonucleases
|
|
Concept
|
Polymerase Chain Reaction
|
|
Concept
|
Free Radical Scavengers
|
|
Concept
|
Genes, fos
|
|
Concept
|
Magnetic Resonance Imaging, Cine
|
|
Concept
|
GTP-Binding Proteins
|
|
Concept
|
Dietary Supplements
|
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
|
Concept
|
Calcium-Calmodulin-Dependent Protein Kinases
|
|
Concept
|
In Situ Nick-End Labeling
|
|
Concept
|
Surface Plasmon Resonance
|
|
Concept
|
Comet Assay
|
|
Concept
|
cdc42 GTP-Binding Protein
|
|
Concept
|
Son of Sevenless Protein, Drosophila
|
|
Concept
|
Imaging, Three-Dimensional
|
|
Concept
|
Secretory Vesicles
|
|
Concept
|
Gene Knockdown Techniques
|
|
Concept
|
Homeodomain Proteins
|
|
Concept
|
Nitric Oxide Synthase
|
|
Concept
|
Endangered Species
|
|
Concept
|
Cation Transport Proteins
|
|
Concept
|
Monomeric GTP-Binding Proteins
|
|
Concept
|
GTPase-Activating Proteins
|
|
Concept
|
MAP Kinase Signaling System
|
|
Concept
|
Protein Sorting Signals
|
|
Concept
|
JNK Mitogen-Activated Protein Kinases
|
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
|
Concept
|
Bariatric Surgery
|
|
Concept
|
STAT5 Transcription Factor
|
|
Concept
|
Proteostasis Deficiencies
|
|
Concept
|
GRB2 Adaptor Protein
|
|
Concept
|
Neural Stem Cells
|
|
Concept
|
Transcriptome
|
|
Concept
|
Protein Tyrosine Phosphatase, Non-Receptor Type 1
|
|
Concept
|
Genome-Wide Association Study
|
|
Concept
|
AMP-Activated Protein Kinases
|
|
Concept
|
Bone Morphogenetic Protein 6
|
|
Concept
|
Insulin Receptor Substrate Proteins
|
|
Concept
|
Mendelian Randomization Analysis
|
|
Concept
|
Precision Medicine
|
|
Concept
|
RNA, Small Interfering
|
|
Concept
|
Fluorescence Recovery After Photobleaching
|
|
Concept
|
Ribosomal Protein S6 Kinases, 70-kDa
|
|
Concept
|
Protein Interaction Maps
|
|
Concept
|
Intracellular Signaling Peptides and Proteins
|
|
Concept
|
Cell Size
|
|
Concept
|
Cell Shape
|
|
Concept
|
Suppressor of Cytokine Signaling Proteins
|
|
Concept
|
Protein Kinase C-alpha
|
|
Concept
|
ADAM Proteins
|
|
Concept
|
Nitric Oxide Synthase Type III
|
|
Concept
|
Amyloid Precursor Protein Secretases
|
|
Concept
|
Agouti-Related Protein
|
|
Concept
|
Drug Discovery
|
|
Concept
|
Gene Knock-In Techniques
|
|
Concept
|
Diet, High-Fat
|
|
Concept
|
Autopsy
|
|
Concept
|
Blood Chemical Analysis
|
|
Concept
|
Calcium-Binding Proteins
|
|
Concept
|
Carrier Proteins
|
|
Concept
|
Cell Survival
|
|
Concept
|
Cloning, Molecular
|
|
Concept
|
Cytoskeletal Proteins
|
|
Concept
|
Follow-Up Studies
|
|
Concept
|
Luminescent Proteins
|
|
Concept
|
Magnetic Resonance Imaging
|
|
Concept
|
Microscopy, Fluorescence
|
|
Concept
|
Microtomy
|
|
Concept
|
Nuclear Proteins
|
|
Concept
|
Organ Specificity
|
|
Concept
|
Prospective Studies
|
|
Concept
|
Protons
|
|
Concept
|
Herpesvirus 1, Suid
|
|
Concept
|
Rats, Mutant Strains
|
|
Concept
|
Recombinant Fusion Proteins
|
|
Concept
|
Retrospective Studies
|
|
Concept
|
Seawater
|
|
Concept
|
Serine Endopeptidases
|
|
Concept
|
Spermatozoa
|
|
Concept
|
Sphingosine
|
|
Concept
|
Spinal Cord
|
|
Concept
|
Subtilisins
|
|
Concept
|
Gastric Bypass
|
|
Concept
|
Signal Transduction
|
|
Concept
|
Tumor Suppressor Protein p53
|
|
Concept
|
Granulocyte-Macrophage Colony-Stimulating Factor
|
|
Concept
|
Kallikrein-Kinin System
|
|
Concept
|
Conserved Sequence
|
|
Concept
|
Sequence Analysis, RNA
|
|
Concept
|
Cyclic AMP-Dependent Protein Kinases
|
|
Concept
|
Electroporation
|
|
Concept
|
Coculture Techniques
|
|
Concept
|
Spin Trapping
|
|
Concept
|
Protein Isoforms
|
|
Concept
|
Polymorphism, Single Nucleotide
|
|
Concept
|
Quantitative Structure-Activity Relationship
|
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Concept
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Membrane Transport Proteins
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Concept
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Vesicular Transport Proteins
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Concept
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Adaptor Proteins, Vesicular Transport
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Concept
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Quantitative Trait Loci
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Concept
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Tissue Culture Techniques
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Concept
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Microscopy, Electron, Transmission
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Concept
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Macromolecular Substances
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Concept
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Protein Kinase Inhibitors
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Concept
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Peroxisome Proliferator-Activated Receptors
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Concept
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p38 Mitogen-Activated Protein Kinases
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Concept
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Proto-Oncogene Proteins c-akt
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Concept
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Bone Morphogenetic Protein Receptors
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Concept
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Receptor-Like Protein Tyrosine Phosphatases, Class 8
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Concept
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Infusions, Subcutaneous
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Concept
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Research Report
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Academic Article
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Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
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Academic Article
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Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases.
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Academic Article
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A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
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Academic Article
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The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
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Academic Article
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
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Academic Article
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Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
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Academic Article
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Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
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Academic Article
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Insulin-secreting non-islet cells are resistant to autoimmune destruction.
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Academic Article
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The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
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Academic Article
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Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
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Academic Article
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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
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Academic Article
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
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Academic Article
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
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Academic Article
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
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Academic Article
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Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
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Academic Article
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How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats.
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Academic Article
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
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Academic Article
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
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Academic Article
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
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Academic Article
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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
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Academic Article
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
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Academic Article
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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
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Academic Article
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Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
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Academic Article
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
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Academic Article
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
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Academic Article
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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
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Academic Article
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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
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Academic Article
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A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
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Academic Article
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Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
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Academic Article
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Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set?
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Academic Article
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Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
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Academic Article
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
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Academic Article
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Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
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Academic Article
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
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Academic Article
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Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.
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Academic Article
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Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
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Academic Article
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
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Academic Article
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Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.
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Academic Article
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A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
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Academic Article
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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
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Academic Article
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Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
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Academic Article
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
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Academic Article
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Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
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Academic Article
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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
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Academic Article
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Type 2 diabetes-a matter of beta-cell life and death?
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Academic Article
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Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.
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Academic Article
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10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?
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Academic Article
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
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Academic Article
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Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
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Academic Article
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Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
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Academic Article
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Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
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Academic Article
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Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
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Academic Article
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
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Academic Article
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
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Academic Article
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
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Academic Article
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Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?
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Academic Article
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Proinsulin maturation, misfolding, and proteotoxicity.
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Academic Article
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
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Academic Article
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Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
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Academic Article
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Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
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Academic Article
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Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
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Academic Article
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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
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Academic Article
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Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.
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Academic Article
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Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules.
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Academic Article
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[Biogenesis of the insulin secretion granule].
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Academic Article
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Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.
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Academic Article
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
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Academic Article
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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
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Academic Article
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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
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Academic Article
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
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Academic Article
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The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides.
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Academic Article
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
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Academic Article
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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
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Academic Article
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The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
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Academic Article
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Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.
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Academic Article
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
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Academic Article
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Academic Article
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
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Academic Article
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Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets.
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Academic Article
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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
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Academic Article
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
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Academic Article
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Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
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Academic Article
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Formation of a human ß-cell population within pancreatic islets is set early in life.
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Academic Article
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Degradation of islet amyloid polypeptide by neprilysin.
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Academic Article
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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
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Academic Article
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High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin.
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Academic Article
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How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
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Academic Article
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2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets.
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Academic Article
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Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
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Academic Article
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
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Academic Article
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A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
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Academic Article
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What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
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Academic Article
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
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Academic Article
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Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.
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Academic Article
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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
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Academic Article
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Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.
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Academic Article
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
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Academic Article
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The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide.
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Academic Article
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Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.
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Academic Article
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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
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Academic Article
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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
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Academic Article
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Molecular insights into insulin action and secretion.
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Academic Article
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
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Academic Article
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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
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Academic Article
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
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Academic Article
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Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.
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Academic Article
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Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
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Academic Article
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Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
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Academic Article
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The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
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Academic Article
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
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Academic Article
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Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.
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Academic Article
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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
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Academic Article
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Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
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Academic Article
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Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets.
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Academic Article
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Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
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Academic Article
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Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.
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Academic Article
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Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin.
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Academic Article
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
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Academic Article
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Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.
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Academic Article
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IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
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Academic Article
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
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Academic Article
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Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus.
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Academic Article
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
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Academic Article
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Intracellular signalling. Key enzyme in leptin-induced anorexia.
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Academic Article
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.
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Academic Article
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Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala.
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Academic Article
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ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
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Academic Article
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Islet autoantigens: structure, function, localization, and regulation.
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Academic Article
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Direct autocrine action of insulin on ß-cells: does it make physiological sense?
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Academic Article
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Characterization of the promoter for the rat and human link protein gene.
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Academic Article
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Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells.
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Academic Article
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Absolute quantification of myocardial blood flow with H(2)(15)O and 3-dimensional PET: an experimental validation.
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Academic Article
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a1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.
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Academic Article
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
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Academic Article
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Ensuring quality in a computerized database system: a perinatal network.
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Academic Article
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Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
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Academic Article
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Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
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Academic Article
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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
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Academic Article
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SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
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Academic Article
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In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.
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Academic Article
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Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.
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Academic Article
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Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity.
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Academic Article
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40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.
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Academic Article
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Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.
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Academic Article
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Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
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Academic Article
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Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study.
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Academic Article
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
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Academic Article
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Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
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Academic Article
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Ca(2+)-regulated serine protease associated with the nuclear scaffold.
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Academic Article
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Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.
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Academic Article
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Solar energy: principles and possibilities.
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Academic Article
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TaqI and HaeIII RFLP polymorphisms in human proteoglycan link gene (CRTL1).
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Academic Article
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Can solar fuels avert an imminent petroleum fuel crisis?
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Academic Article
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The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription.
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Academic Article
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Rising sea levels - by how much, and why?
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Academic Article
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Plastic pollution and potential solutions.
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Academic Article
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Epidemiology of communicable disease in small populations.
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Academic Article
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BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH.
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Academic Article
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Rabies and canine distemper virus epidemics in the red fox population of northern Italy (2006-2010).
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Academic Article
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Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene.
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Academic Article
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The 2015 Paris Climate Change Conference: COP21.
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Academic Article
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Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.
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Academic Article
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Leptin action in the forebrain regulates the hindbrain response to satiety signals.
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Academic Article
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Perovskites - some snapshots of recent developments.
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Academic Article
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The imperative for regenerative agriculture.
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Academic Article
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The global oil supply - prevailing situation and prognosis.
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Academic Article
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Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension.
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Academic Article
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An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
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Academic Article
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Unpaired electrons as probes of catalytic systems.
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Academic Article
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Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension.
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Academic Article
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Diuretics for preventing pre-eclampsia.
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Academic Article
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Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1.
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Academic Article
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Muonium--the second radioisotope of hydrogen: a remarkable and unique radiotracer in the chemical, materials, biological and environmental sciences.
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Academic Article
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Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
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Academic Article
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The price of oil.
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Academic Article
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Modelling the influence of foot-and-mouth disease vaccine antigen stability and dose on the bovine immune response.
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Academic Article
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Expansion of the Knockdown Resistance Frequency Map for Human Head Lice (Phthiraptera: Pediculidae) in the United States Using Quantitative Sequencing.
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Academic Article
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Exclusion of human proteoglycan link protein (CRTL1) and type II collagen (COL2A1) genes in pseudoachondroplasia.
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Academic Article
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Complex interactions with females and rival males limit the evolution of sperm offence and defence.
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Academic Article
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Photocatalysts based on graphitic carbon nitride: some prospects for artificial photosynthesis and the remediation of environmental pollution.
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Academic Article
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Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin.
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Academic Article
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Muon tomography: looking inside dangerous places.
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Academic Article
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Epidemic thresholds and vaccination in a lattice model of disease spread.
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Academic Article
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Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules.
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Academic Article
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Applications of bioremediation and phytoremediation.
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Academic Article
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Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights.
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Academic Article
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"Spin-labelling" with the second hydrogen radioisotope: radicals formed from squalene by muonium addition.
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Academic Article
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Intracoronary endothelin induces myocardial ischemia by small vessel constriction in the dog.
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Academic Article
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GT repeat polymorphism in the human proteoglycan link gene (CRTL1) promoter region.
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Academic Article
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A determination of antioxidant efficiencies using ESR and computational methods.
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Academic Article
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Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2.).
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Academic Article
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Pollinator decline - an ecological calamity in the making?
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Academic Article
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Feeding and healing the world: through regenerative agriculture and permaculture.
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Academic Article
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Carbon capture and storage.
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Academic Article
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Current commentary: thorium-based nuclear power.
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Alternative splicing generates two different mRNA species for rat link protein.
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Eating small: applications and implications for nano-technology in agriculture and the food industry.
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The Fukushima Daiichi nuclear accident.
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Single molecule tracking on supported membranes with arrays of optical nanoantennas.
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Evolutionary entropy determines invasion success in emergent epidemics.
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Current commentary: Can free radicals be good for you?
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Ionic liquids and green futures.
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Novel catalysts for water splitting and green chemistry applications.
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Roman concrete for durable, eco-friendly construction - applications for tidal power generation, and protection against sea level rise.
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The 2016 Nobel Prize for Chemistry, awarded for: "The Design and Synthesis of Molecular Machines".
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Oil from algae; salvation from peak oil?
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The whispering world of plants: 'The Wood Wide Web'.
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The effect of superspreading on epidemic outbreak size distributions.
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Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension.
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Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future.
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Therapeutic targets in pulmonary arterial hypertension.
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Permaculture: regenerative--not merely sustainable.
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Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array.
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Pulmonary arterial hypertension - progress in understanding the disease and prioritizing strategies for drug development.
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Soil erosion, climate change and global food security: challenges and strategies.
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The human genome contains a pseudogene for the Mr=32,000 laminin binding protein.
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Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
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Properties and applications of zeolites.
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The Diamond Light Source.
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Biochar, and its potential contribution to improving soil quality and carbon capture.
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Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction.
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Peak phosphorus - peak food? The need to close the phosphorus cycle.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer.
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Electron spin resonance. Part one: a diagnostic method in the biomedical sciences.
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Muon spectroscopy applied to biological systems: a study of thiyl radicals, RS.
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Simvastatin as a treatment for pulmonary hypertension trial.
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"Vibrational bonding": a new type of chemical bond is discovered.
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Role of oxygen radicals in DNA damage and cancer incidence.
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Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study.
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Arsenic: toxicity, oxidative stress and human disease.
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Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity.
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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
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Identification of the Novel Tooth-Specific Transcription Factor AmeloD.
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ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats.
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The oil question: nature and prognosis.
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On the critical behaviour of simple epidemics.
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Muonium addition to DMPO and PBN sorbed in silica-gel.
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PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
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Plasmonic nanoparticles and solar cells.
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Current Commentary Recent Developments in Solar Energy Applications based on Perovskites: A Current Commentary.
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Variational data assimilation with epidemic models.
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Perovskites and their potential use in solar energy applications.
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Contact rate calculation for a basic epidemic model.
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Energy from nuclear fusion--realities, prospects and fantasies?
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Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.
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Academic Article
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Redox- and non-redox-metal-induced formation of free radicals and their role in human disease.
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Academic Article
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US withdrawal from the COP21 Paris Climate Change Agreement, and its possible implications.
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Magnetic resonance spectroscopy.
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Sustainable nanotechnology.
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Fossil fuel use is limited by climate, if not by resources, and "peak soil"..
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Shortage of resources for renewable energy and food production.
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The dynamic plasticity of insulin production in ß-cells.
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The enzymology of proinsulin conversion.
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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
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Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.
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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
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Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis.
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Photonics.
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Electron spin resonance. Part two: a diagnostic method in the environmental sciences.
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Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
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Large Hadron Collider (LHC).
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The influence of viral infection on a plankton ecosystem undergoing nutrient enrichment.
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Genetically modified algae produce hydrogen biofuel at five times their normal yield.
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A radiolabelling study of radicals derived from benzene, toluene and benzaldehyde sorbed in model environmental carbon.
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Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
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Academic Article
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Metabolic pathways associated with right ventricular adaptation to pulmonary hypertension: 3D analysis of cardiac magnetic resonance imaging.
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Academic Article
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Biosynthesis and storage of insulin.
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Academic Article
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The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension.
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Academic Article
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Unsuitability of indoxyl acetate as a substrate for the assay of testicular hyaluronidase.
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Academic Article
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
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Academic Article
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Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis.
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Academic Article
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Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
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Academic Article
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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
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Academic Article
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Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma.
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Academic Article
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
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Academic Article
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Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.
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Academic Article
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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension.
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Academic Article
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Endangered elements, critical raw materials and conflict minerals.
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Academic Article
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Are insect species imperilled? Critical factors and prevailing evidence for a potential global loss of the entomofauna: A current commentary.
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Academic Article
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Only 12 years left to readjust for the 1.5-degree climate change option - Says International Panel on Climate Change report: Current commentary.
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Solving the plastic problem: From cradle to grave, to reincarnation.
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Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
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Academic Article
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Targeting Vessel Formation in Pulmonary Arterial Hypertension: Is the Endostatin-Id1-Thrombospondin 1 Pathway a New Hope?
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.
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Academic Article
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Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
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The application of 'omics' to pulmonary arterial hypertension.
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The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Academic Article
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A fluorescent timer reporter enables sorting of insulin secretory granules by age.
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Academic Article
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Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome.
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Academic Article
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Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.
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Academic Article
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Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension.
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Academic Article
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The cancer hypothesis of pulmonary arterial hypertension: are polyamines the new Warburg?
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Academic Article
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Bayesian Inference Associates Rare KDR Variants with Specific Phenotypes in Pulmonary Arterial Hypertension.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Academic Article
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A fluorescent timer reporter enables sorting of insulin secretory granules by age.
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Academic Article
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Antioxidant vs. Prooxidant Properties of the Flavonoid, Kaempferol, in the Presence of Cu(II) Ions: A ROS-Scavenging Activity, Fenton Reaction and DNA Damage Study.
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Academic Article
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The pathophysiological role of novel pulmonary arterial hypertension gene SOX17.
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Academic Article
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Supplementation with Iron in Pulmonary Arterial Hypertension. Two Randomized Crossover Trials.
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Academic Article
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A genetic map of the mouse dorsal vagal complex and its role in obesity.
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Academic Article
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Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial.
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Academic Article
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NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.
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Academic Article
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A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach.
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Academic Article
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Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
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Academic Article
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NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity.
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Academic Article
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NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain.
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Academic Article
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World scientists' warnings into action, local to global.
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Academic Article
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Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
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Academic Article
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BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice.
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Academic Article
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Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
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Academic Article
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Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension.
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Academic Article
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Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain.
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Academic Article
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Autoimmunity Is a Significant Feature of Idiopathic Pulmonary Arterial Hypertension.
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Academic Article
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Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension.
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Academic Article
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Calcineurin/NFATc2 and PI3K/AKT signaling maintains ß-cell identity and function during metabolic and inflammatory stress.
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Academic Article
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Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis.
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Academic Article
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Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life.
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Academic Article
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Who knew? PPARs may act in the brain too.
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Academic Article
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An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
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Academic Article
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Cytokines as prognostic biomarkers in pulmonary arterial hypertension.
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Academic Article
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PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
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Academic Article
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Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
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Academic Article
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Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension.
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Academic Article
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Essential metals in health and disease.
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Academic Article
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High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity.
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Academic Article
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Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.
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Concept
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Clinical Studies as Topic
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Concept
|
Forkhead Box Protein O1
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Concept
|
Suppressor of Cytokine Signaling 3 Protein
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Concept
|
ADAM10 Protein
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Concept
|
ADAMTS13 Protein
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Concept
|
Snail Family Transcription Factors
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|
Concept
|
Uncoupling Protein 1
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Concept
|
Forkhead Box Protein O3
|
|
Concept
|
Src Homology 2 Domain-Containing, Transforming Protein 1
|
|
Concept
|
Proprotein Convertase 9
|
|
Concept
|
Glycogen Synthase Kinase 3 beta
|
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Concept
|
Soluble Guanylyl Cyclase
|
|
Concept
|
Serrate-Jagged Proteins
|
|
Concept
|
Jagged-1 Protein
|
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Concept
|
Superoxide Dismutase-1
|
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Concept
|
Whole Genome Sequencing
|
|
Concept
|
Dietary Sugars
|
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Concept
|
Short Stature Homeobox Protein
|
|
Concept
|
Regulatory-Associated Protein of mTOR
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Concept
|
Sf9 Cells
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Concept
|
Gene Ontology
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Concept
|
CRISPR-Cas Systems
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Concept
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Protein Kinase C beta
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Concept
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3-Phosphoinositide-Dependent Protein Kinases
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Concept
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In Vitro Techniques
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Concept
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Electronic Nicotine Delivery Systems
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Grant
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Mitogenic Signal Transduction in Pancreatic Beta-Cells
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Grant
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Metabolic Control of Insulin Exocytosis
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Grant
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Central Control of Pancreatic Islet Function
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Grant
|
Western Region Islet Study Group
|
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Grant
|
An Interdisciplinary Molecular Metabolism Training Program
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Academic Article
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Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH.
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Academic Article
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Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension.
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Academic Article
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SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
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Academic Article
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The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions.
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Academic Article
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World scientists' warning: The behavioural crisis driving ecological overshoot.
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Academic Article
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The SOX17 phenotype in pulmonary arterial hypertension: lessons for pathobiology and clinical management.
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Academic Article
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Response by Walters et al to Letter Regarding Article, "SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension".
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Academic Article
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Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.
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Academic Article
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
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Academic Article
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Multi-biobank summary data Mendelian randomisation does not support a causal effect of IL-6 signalling on risk of pulmonary arterial hypertension.
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Academic Article
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Mendelian Randomization Study With Clinical Follow-Up Links Metabolites to Risk and Severity of Pulmonary Arterial Hypertension.
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Academic Article
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Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism.
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